Ontology highlight
ABSTRACT:
SUBMITTER: Muller J
PROVIDER: S-EPMC4428333 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141215
Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is associated with more severe resistance to a range of inhibitors, while its presence is required for robust drug responses. Both in primary and acquired resistance, MITF levels inversely correlate with the expression of several activated receptor tyrosine kinases, most frequently AXL. The MITF-low/AXL ...[more]