Ontology highlight
ABSTRACT:
SUBMITTER: Hentzschel F
PROVIDER: S-EPMC4429697 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Hentzschel Franziska F Hammerschmidt-Kamper Christiane C Börner Kathleen K Heiss Kirsten K Knapp Bettina B Sattler Julia M JM Kaderali Lars L Castoldi Mirco M Bindman Jay G JG Malato Yann Y Willenbring Holger H Mueller Ann-Kristin AK Grimm Dirk D
Molecular therapy : the journal of the American Society of Gene Therapy 20140905 12
Malaria, caused by protozoan Plasmodium parasites, remains a prevalent infectious human disease due to the lack of an efficient and safe vaccine. This is directly related to the persisting gaps in our understanding of the parasite's interactions with the infected host, especially during the clinically silent yet essential liver stage of Plasmodium development. Previously, we and others showed that genetically attenuated parasites (GAP) that arrest in the liver induce sterile immunity, but only u ...[more]