Ontology highlight
ABSTRACT:
SUBMITTER: Bunse M
PROVIDER: S-EPMC4429734 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Bunse Mario M Bendle Gavin M GM Linnemann Carsten C Bies Laura L Schulz Stephan S Schumacher Ton N TN Uckert Wolfgang W
Molecular therapy : the journal of the American Society of Gene Therapy 20140722 11
Genetically modified T cells that express a transduced T cell receptor (TCR) α/β heterodimer in addition to their endogenous TCR are used in clinical studies to treat cancer. These cells express two TCR-α and two TCR-β chains that do not only compete for CD3 proteins but also form potentially self-reactive mixed TCR dimers, composed of endogenous and transferred chains. To overcome these deficits, we developed an RNAi-TCR replacement vector that simultaneously silences the endogenous TCR and exp ...[more]