Ontology highlight
ABSTRACT:
SUBMITTER: Engeland CE
PROVIDER: S-EPMC4429737 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Engeland Christine E CE Grossardt Christian C Veinalde Rūta R Bossow Sascha S Lutz Diana D Kaufmann Johanna K JK Shevchenko Ivan I Umansky Viktor V Nettelbeck Dirk M DM Weichert Wilko W Jäger Dirk D von Kalle Christof C Ungerechts Guy G
Molecular therapy : the journal of the American Society of Gene Therapy 20140826 11
We hypothesized that the combination of oncolytic virotherapy with immune checkpoint modulators would reduce tumor burden by direct cell lysis and stimulate antitumor immunity. In this study, we have generated attenuated Measles virus (MV) vectors encoding antibodies against CTLA-4 and PD-L1 (MV-aCTLA-4 and MV-aPD-L1). We characterized the vectors in terms of growth kinetics, antibody expression, and cytotoxicity in vitro. Immunotherapeutic effects were assessed in a newly established, fully imm ...[more]