PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer.
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ABSTRACT:
SUBMITTER: Hartkopf AD
PROVIDER: S-EPMC5290437 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer.
Hartkopf Andreas D AD Taran Florin-Andrei FA Wallwiener Markus M Walter Christina B CB Krämer Bernhard B Grischke Eva-Maria EM Brucker Sara Y SY
Breast care (Basel, Switzerland) 20161208 6
Immune checkpoint inhibition represents a major recent breakthrough in the treatment of malignant diseases including breast cancer. Blocking the programmed death receptor-1 (PD-1) and its ligand, PD-L1, has shown impressive antitumor activity and may lead to durable long-term disease control, especially in the triple-negative subtypes of breast cancer (TNBC). Although immune checkpoint blockade is generally well tolerated, specific immune-related adverse events (irAEs) may occur. This review sum ...[more]
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