Ontology highlight
ABSTRACT:
SUBMITTER: Dieckman LM
PROVIDER: S-EPMC4429884 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Dieckman Lynne M LM Freudenthal Bret D BD Washington M Todd MT
Sub-cellular biochemistry 20120101
Proliferating cell nuclear antigen (PCNA), the eukaryotic DNA sliding clamp, forms a ring-shaped homo-trimer that encircles double-stranded DNA. This protein is best known for its ability to confer high processivity to replicative DNA polymerases. However, it does far more than this, because it forms a mobile platform on the DNA that recruits many of the proteins involved in DNA replication, repair, and recombination to replication forks. X-ray crystal structures of PCNA bound to PCNA-binding pr ...[more]