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PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA.


ABSTRACT: Proliferating cell nuclear antigen (PCNA), the eukaryotic DNA sliding clamp, forms a ring-shaped homo-trimer that encircles double-stranded DNA. This protein is best known for its ability to confer high processivity to replicative DNA polymerases. However, it does far more than this, because it forms a mobile platform on the DNA that recruits many of the proteins involved in DNA replication, repair, and recombination to replication forks. X-ray crystal structures of PCNA bound to PCNA-binding proteins have provided insights into how PCNA recognizes its binding partners and recruits them to replication forks. More recently, X-ray crystal structures of ubiquitin-modified and SUMO-modified PCNA have provided insights into how these post-translational modifications alter the specificity of PCNA for some of its binding partners. This article focuses on the insights gained from structural studies of PCNA complexes and post-translationally modified PCNA.

SUBMITTER: Dieckman LM 

PROVIDER: S-EPMC4429884 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA.

Dieckman Lynne M LM   Freudenthal Bret D BD   Washington M Todd MT  

Sub-cellular biochemistry 20120101


Proliferating cell nuclear antigen (PCNA), the eukaryotic DNA sliding clamp, forms a ring-shaped homo-trimer that encircles double-stranded DNA. This protein is best known for its ability to confer high processivity to replicative DNA polymerases. However, it does far more than this, because it forms a mobile platform on the DNA that recruits many of the proteins involved in DNA replication, repair, and recombination to replication forks. X-ray crystal structures of PCNA bound to PCNA-binding pr  ...[more]

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