Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression.
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ABSTRACT:
SUBMITTER: Platt C
PROVIDER: S-EPMC4430212 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression.
Platt Craig C Calimano Maria M Nemet Josip J Bubenik Jodi J Cochrane Alan A
PloS one 20150513 5
Balanced processing of HIV-1 RNA is critical to virus replication and is regulated by host factors. In this report, we demonstrate that overexpression of either Tra2α or Tra2β results in a marked reduction in HIV-1 Gag/Env expression, an effect associated with changes in HIV-1 RNA accumulation, altered viral splice site usage, and a block to export of HIV-1 genomic RNA. A natural isoform of Tra2β (Tra2ß3), lacking the N-terminal RS domain, also suppressed HIV-1 expression but had different effec ...[more]
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