Ontology highlight
ABSTRACT:
SUBMITTER: Sjogren B
PROVIDER: S-EPMC4430315 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Sjögren Benita B Swaney Steven S Neubig Richard R RR
PloS one 20150513 5
The ubiquitin-proteasome system for protein degradation plays a major role in regulating cell function and many signaling proteins are tightly controlled by this mechanism. Among these, Regulator of G Protein Signaling 2 (RGS2) is a target for rapid proteasomal degradation, however, the specific enzymes involved are not known. Using a genomic siRNA screening approach, we identified a novel E3 ligase complex containing cullin 4B (CUL4B), DNA damage binding protein 1 (DDB1) and F-box protein 44 (F ...[more]