Ontology highlight
ABSTRACT:
SUBMITTER: Lanuti M
PROVIDER: S-EPMC4430319 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Lanuti Mirko M Talamonti Emanuela E Maccarrone Mauro M Chiurchiù Valerio V
PloS one 20150513 5
The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with bone remodelling, nervous system excitability, vascular homeostasis as well as in several pathophysiological conditions including obesity and cancer. However, its physiological role and underlying mechanism remain unclear. In the present work, we demonstrate for the first time its presence in human macrophages and its increased expression in ox-LDL-induced foam cells. In addition, pharmacological ...[more]