Ontology highlight
ABSTRACT:
SUBMITTER: de Boer R
PROVIDER: S-EPMC4430419 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
de Boer Richard R Smith Ruben L RL De Vos Winnok H WH Manders Erik M M EM Brul Stanley S van der Spek Hans H
PloS one 20150513 5
Today HIV-1 infection is recognized as a chronic disease with obligatory lifelong treatment to keep viral titers below detectable levels. The continuous intake of antiretroviral drugs however, leads to severe and even life-threatening side effects, supposedly by the deleterious impact of nucleoside-analogue type compounds on the functioning of the mitochondrial DNA polymerase. For detailed investigation of the yet partially understood underlying mechanisms, the availability of a versatile model ...[more]