Ontology highlight
ABSTRACT:
SUBMITTER: Brown JS
PROVIDER: S-EPMC4431666 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Cell reports 20150423 5
The activities of many DNA-repair proteins are controlled through reversible covalent modification by ubiquitin and ubiquitin-like molecules. Nonhomologous end-joining (NHEJ) is the predominant DNA double-strand break (DSB) repair pathway in mammalian cells and is initiated by DSB ends being recognized by the Ku70/Ku80 (Ku) heterodimer. By using MLN4924, an anti-cancer drug in clinical trials that specifically inhibits conjugation of the ubiquitin-like protein, NEDD8, to target proteins, we demo ...[more]