Ontology highlight
ABSTRACT:
SUBMITTER: Polanowska J
PROVIDER: S-EPMC1462971 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Polanowska Jolanta J Martin Julie S JS Garcia-Muse Tatiana T Petalcorin Mark I R MI Boulton Simon J SJ
The EMBO journal 20060420 10
The BRCA1 tumour suppressor and its heterodimeric partner BARD1 constitute an E3-ubiquitin (Ub) ligase and function in DNA repair by unknown mechanisms. We show here that the Caenorhabditis elegans BRCA1/BARD1 (CeBCD) complex possesses an E3-Ub ligase responsible for ubiquitylation at DNA damage sites following ionizing radiation (IR). The DNA damage checkpoint promotes the association of the CeBCD complex with E2-Ub conjugating enzyme, Ubc5(LET-70), leading to the formation of an active E3-Ub l ...[more]