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Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics.

ABSTRACT: We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed.

SUBMITTER: Farmer AR

PROVIDER: S-EPMC4432035 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics.

Farmer Aaron R AR Murray Clinton K CK Driscoll Ian R IR Wickes Brian L BL Wiederhold Nathan N Sutton Deanna A DA Sanders Carmita C Mende Katrin K Enniss Brent B Feig James J Ganesan Anuradha A Rini Elizabeth A EA Vento Todd J TJ

Journal of clinical microbiology 20150401 6

We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence- and culture-confirmed Pythium aphanidermatum wound infection. Antemortem histopathology suggested disseminated Pythium infection, including brain involvement; however, postmortem PCR revealed Cunninghamella elegans, Lichtheimia corymbifera, and Saksenaea vasiformis coinfection. The utility of molecular diagnostics in invasive fungal infections is discussed. ...[more]

PMID: 25832301

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