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CARB-17 family of ?-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

ABSTRACT: Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing ?-lactamase (CARB) family of ?-lactamases, bla(CARB-17), was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, bla(CARB-17)-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemolyticus food isolates, further confirming the intrinsic nature of this gene.

SUBMITTER: Chiou J

PROVIDER: S-EPMC4432138 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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CARB-17 family of β-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.

Chiou Jiachi J Li Ruichao R Chen Sheng S

Antimicrobial agents and chemotherapy 20150323 6

Vibrio parahaemolyticus is commonly resistant to ampicillin, yet the mechanisms underlying this phenomenon are not clear. In this study, a novel class A carbenicillin-hydrolyzing β-lactamase (CARB) family of β-lactamases, bla(CARB-17), was identified and found to be responsible for the intrinsic penicillin resistance in V. parahaemolyticus. Importantly, bla(CARB-17)-like genes were present in all 293 V. parahaemolyticus genome sequences available in GenBank and detectable in all 91 V. parahaemol ...[more]

PMID: 25801555

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