Ontology highlight
ABSTRACT:
SUBMITTER: Qin Z
PROVIDER: S-EPMC4432587 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Qin Zhao Z Hubbard E Jane Albert EJ
Nature communications 20150511
Stem cells maintain tissues and organs over the lifespan of individuals. How aging influences this process is unclear. Here we investigate the effects of aging on C. elegans germline stem/progenitor cells and show that the progenitor pool is depleted over time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS). Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is required for germline progenitor maintenance, and that this role is separab ...[more]