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MAS NMR of HIV-1 protein assemblies.

ABSTRACT: The negative global impact of the AIDS pandemic is well known. In this perspective article, the utility of magic angle spinning (MAS) NMR spectroscopy to answer pressing questions related to the structure and dynamics of HIV-1 protein assemblies is examined. In recent years, MAS NMR has undergone major technological developments enabling studies of large viral assemblies. We discuss some of these evolving methods and technologies and provide a perspective on the current state of MAS NMR as applied to the investigations into structure and dynamics of HIV-1 assemblies of CA capsid protein and of Gag maturation intermediates.

SUBMITTER: Suiter CL

PROVIDER: S-EPMC4432874 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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MAS NMR of HIV-1 protein assemblies.

Suiter Christopher L CL Quinn Caitlin M CM Lu Manman M Hou Guangjin G Zhang Huilan H Polenova Tatyana T

Journal of magnetic resonance (San Diego, Calif. : 1997) 20150401

The negative global impact of the AIDS pandemic is well known. In this perspective article, the utility of magic angle spinning (MAS) NMR spectroscopy to answer pressing questions related to the structure and dynamics of HIV-1 protein assemblies is examined. In recent years, MAS NMR has undergone major technological developments enabling studies of large viral assemblies. We discuss some of these evolving methods and technologies and provide a perspective on the current state of MAS NMR as appli ...[more]

PMID: 25797001

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