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Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis.

ABSTRACT: Antimicrobial drug discovery has slowed considerably over the last few decades. One major cause for concern is the lack of innovative approaches to treat infections caused by mycobacteria such as TB. Herein we demonstrate that our Small Molecule Variable Ligand Display (SMLVD) method for nanoparticle antibiotic discovery can be expanded around a ligand feed ratio parameter space to identify gold nanoparticle conjugates that are potent inhibitors of mycobacteria growth, with our most potent inhibitor able to reduce growth by five orders of magnitude at 8 ?M.

SUBMITTER: Gifford JC

PROVIDER: S-EPMC4433471 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis.

Gifford Jennifer C JC Bresee Jamee J Carter Carly Jo CJ Wang Guankui G Melander Roberta J RJ Melander Christian C Feldheim Daniel L DL

Chemical communications (Cambridge, England) 20141201 100

Antimicrobial drug discovery has slowed considerably over the last few decades. One major cause for concern is the lack of innovative approaches to treat infections caused by mycobacteria such as TB. Herein we demonstrate that our Small Molecule Variable Ligand Display (SMLVD) method for nanoparticle antibiotic discovery can be expanded around a ligand feed ratio parameter space to identify gold nanoparticle conjugates that are potent inhibitors of mycobacteria growth, with our most potent inhib ...[more]

PMID: 25350535

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