Ontology highlight
ABSTRACT:
SUBMITTER: O'Hara JM
PROVIDER: S-EPMC4433546 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
O'Hara Joanne M JM Yermakova Anastasiya A Mantis Nicholas J NJ
Current topics in microbiology and immunology 20120101
Ricin toxin is an extraordinarily potent inducer of cell death and inflammation. Ricin is also a potent provocateur of the humoral immune system, eliciting a mixture of neutralizing, non-neutralizing and even toxin-enhancing antibodies. The characterization of dozens of monoclonal antibodies (mAbs) against the toxin's enzymatic (RTA) and binding (RTB) subunits has begun to reveal fundamental insights into the underlying mechanisms by which antibodies neutralize (or fail to neutralize) ricin in s ...[more]