Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease.
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ABSTRACT:
SUBMITTER: Gulino R
PROVIDER: S-EPMC4433663 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
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Novel Mechanisms of Spinal Cord Plasticity in a Mouse Model of Motoneuron Disease.
Gulino Rosario R Parenti Rosalba R Gulisano Massimo M
BioMed research international 20150503
A hopeful spinal cord repairing strategy involves the activation of neural precursor cells. Unfortunately, their ability to generate neurons after injury appears limited. Another process promoting functional recovery is synaptic plasticity. We have previously studied some mechanisms of spinal plasticity involving BDNF, Shh, Notch-1, Numb, and Noggin, by using a mouse model of motoneuron depletion induced by cholera toxin-B saporin. TDP-43 is a nuclear RNA/DNA binding protein involved in amyotrop ...[more]
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