Identification of lead compounds for (99m)Tc and (18)F GPR91 radiotracers.
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ABSTRACT:
SUBMITTER: Klenc J
PROVIDER: S-EPMC4433761 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Identification of lead compounds for (99m)Tc and (18)F GPR91 radiotracers.
Klenc Jeffrey J Lipowska Malgorzata M Taylor Andrew T AT
Bioorganic & medicinal chemistry letters 20150411 11
To develop the first radiotracer targeting GPR91, a cell membrane-bound receptor that modulates the cellular response to hyperglycemia and hypoxia, we designed and prepared a small series of compounds based on a published series of 1,8-naphthyridines with high affinity to GPR91. Our approach provides a mechanism to incorporate radioactive atoms ((99m)Tc and (18)F) into the GPR91 pharmacophore as the final synthetic step. Pharmacological assays confirmed lead compounds for (99m)Tc and (18)F GPR91 ...[more]
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