Ontology highlight
ABSTRACT:
SUBMITTER: Kanayama M
PROVIDER: S-EPMC4433845 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kanayama Masashi M He You-Wen YW Shinohara Mari L ML
Journal of immunology (Baltimore, Md. : 1950) 20150424 11
The lung is constantly exposed to the outer environment; thus, it must maintain a state of immune ignorance or tolerance not to overrespond to harmless environmental stimuli. How cells in the lung control immune responses under nonpathogenic condition is not fully understood. In this study, we found that autophagy plays a critical role in the lung-specific immune regulation that prevents spontaneous inflammation. Autophagy in pulmonary myeloid cells plays a role in maintaining low burdens of env ...[more]