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Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.


ABSTRACT: Autophagy is an important component of the immune response. However, the functions of autophagy in human diseases are much less understood. We studied biological consequences of autophagy deficiency in mice lacking the essential autophagy gene Atg7 or Atg5 in myeloid cells. Surprisingly, these mice presented with spontaneous sterile lung inflammation, characterized by marked recruitment of inflammatory cells, submucosal thickening, goblet cell metaplasia, and increased collagen content. Lung inflammation was associated with increase in several proinflammatory cytokines in the bronchoalveolar lavage and in serum. This inflammation was largely driven by IL-18 as a result of constitutive inflammasome activation. Following i.p. LPS injection, autophagy-deficient mice had higher levels of proinflammatory cytokines in lungs and in serum, as well as increased mortality, than control mice. Intranasal bleomycin challenge exacerbated lung inflammation in autophagy-deficient mice and produced more severe fibrotic changes than in control mice. These results uncover a new and important role for autophagy as negative regulator of lung inflammation.

SUBMITTER: Abdel Fattah E 

PROVIDER: S-EPMC4433854 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.

Abdel Fattah Elmoataz E   Bhattacharya Abhisek A   Herron Alan A   Safdar Zeenat Z   Eissa N Tony NT  

Journal of immunology (Baltimore, Md. : 1950) 20150417 11


Autophagy is an important component of the immune response. However, the functions of autophagy in human diseases are much less understood. We studied biological consequences of autophagy deficiency in mice lacking the essential autophagy gene Atg7 or Atg5 in myeloid cells. Surprisingly, these mice presented with spontaneous sterile lung inflammation, characterized by marked recruitment of inflammatory cells, submucosal thickening, goblet cell metaplasia, and increased collagen content. Lung inf  ...[more]

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