Ontology highlight
ABSTRACT:
SUBMITTER: Abdel Fattah E
PROVIDER: S-EPMC4433854 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Abdel Fattah Elmoataz E Bhattacharya Abhisek A Herron Alan A Safdar Zeenat Z Eissa N Tony NT
Journal of immunology (Baltimore, Md. : 1950) 20150417 11
Autophagy is an important component of the immune response. However, the functions of autophagy in human diseases are much less understood. We studied biological consequences of autophagy deficiency in mice lacking the essential autophagy gene Atg7 or Atg5 in myeloid cells. Surprisingly, these mice presented with spontaneous sterile lung inflammation, characterized by marked recruitment of inflammatory cells, submucosal thickening, goblet cell metaplasia, and increased collagen content. Lung inf ...[more]