Ontology highlight
ABSTRACT:
SUBMITTER: Choi HS
PROVIDER: S-EPMC4434478 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Choi Ha-Soon HS Rucker Paul V PV Wang Zhicheng Z Fan Yi Y Albaugh Pamela P Chopiuk Greg G Gessier Francois F Sun Fangxian F Adrian Francisco F Liu Guoxun G Hood Tami T Li Nanxin N Jia Yong Y Che Jianwei J McCormack Susan S Li Allen A Li Jie J Steffy Auzon A Culazzo AnneMarie A Tompkins Celine C Phung Van V Kreusch Andreas A Lu Min M Hu Bin B Chaudhary Apurva A Prashad Mahavir M Tuntland Tove T Liu Bo B Harris Jennifer J Seidel H Martin HM Loren Jon J Molteni Valentina V
ACS medicinal chemistry letters 20150316 5
Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA have been reported in colorectal, papillary thyroid, glioblastoma, melanoma, and lung tissue that are believed to be the key oncogenic driver in these tumors. By screening the Novartis compound collection, a novel imidazopyridazine TRK inhibitor was id ...[more]