Ontology highlight
ABSTRACT:
SUBMITTER: Niphakis MJ
PROVIDER: S-EPMC3778430 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
ACS chemical neuroscience 20130617 9
Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offer valuable probes to further understand the enzyme's function in biological systems and may lead to drugs for treating a variety of diseases, including psychiatric disorders, neuroinflammation, and pain. N-Hydroxysuccinimidyl (NHS) carbamates have recently been identified as a promising class of ser ...[more]