Dataset Information

Arvicanthis ansorgei, a Novel Model for the Study of Sleep and Waking in Diurnal Rodents.

ABSTRACT:

Study objectives

Sleep neurobiology studies use nocturnal species, mainly rats and mice. However, because their daily sleep/wake organization is inverted as compared to humans, a diurnal model for sleep studies is needed. To fill this gap, we phenotyped sleep and waking in Arvicanthis ansorgei, a diurnal rodent widely used for the study of circadian rhythms.

Design

Video-electroencephalogram (EEG), electromyogram (EMG), and electrooculogram (EOG) recordings.

Setting

Rodent sleep laboratory.

Participants

Fourteen male Arvicanthis ansorgei, aged 3 mo.

Interventions

12 h light (L):12 h dark (D) baseline condition, 24-h constant darkness, 6-h sleep deprivation.

Measurements and results

Wake and rapid eye movement (REM) sleep showed similar electrophysiological characteristics as nocturnal rodents. On average, animals spent 12.9 h ± 0.4 awake per 24-h cycle, of which 6.88 h ± 0.3 was during the light period. NREM sleep accounted for 9.63 h ± 0.4, which of 5.13 h ± 0.2 during dark period, and REM sleep for 89.9 min ± 6.7, which of 52.8 min ± 4.4 during dark period. The time-course of sleep and waking across the 12 h light:12 h dark was overall inverted to that observed in rats or mice, though with larger amounts of crepuscular activity at light and dark transitions. A dominant crepuscular regulation of sleep and waking persisted under constant darkness, showing the lack of a strong circadian drive in the absence of clock reinforcement by external cues, such as a running wheel. Conservation of the homeostatic regulation was confirmed with the observation of higher delta power following sustained waking periods and a 6-h sleep deprivation, with subsequent decrease during recovery sleep.

Conclusions

Arvicanthis ansorgei is a valid diurnal rodent model for studying the regulatory mechanisms of sleep and so represents a valuable tool for further understanding the nocturnality/diurnality switch.

SUBMITTER: Hubbard J

PROVIDER: S-EPMC4434565 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Publications

Arvicanthis ansorgei, a Novel Model for the Study of Sleep and Waking in Diurnal Rodents.

Hubbard Jeffrey J Ruppert Elisabeth E Calvel Laurent L Robin-Choteau Ludivine L Gropp Claire-Marie CM Allemann Caroline C Reibel Sophie S Sage-Ciocca Dominique D Bourgin Patrice P

Sleep 20150601 6

<h4>Study objectives</h4>Sleep neurobiology studies use nocturnal species, mainly rats and mice. However, because their daily sleep/wake organization is inverted as compared to humans, a diurnal model for sleep studies is needed. To fill this gap, we phenotyped sleep and waking in Arvicanthis ansorgei, a diurnal rodent widely used for the study of circadian rhythms.<h4>Design</h4>Video-electroencephalogram (EEG), electromyogram (EMG), and electrooculogram (EOG) recordings.<h4>Setting</h4>Rodent ...[more]

PMID: 25409107

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Dataset Information

Arvicanthis ansorgei, a Novel Model for the Study of Sleep and Waking in Diurnal Rodents.

Study objectives

Design

Setting

Participants

Interventions

Measurements and results

Conclusions

Publications

Arvicanthis ansorgei, a Novel Model for the Study of Sleep and Waking in Diurnal Rodents.

Similar Datasets

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