Ontology highlight
ABSTRACT:
SUBMITTER: Lenstra TL
PROVIDER: S-EPMC4435841 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Lenstra Tineke L TL Benschop Joris J JJ Kim Taesoo T Schulze Julia M JM Brabers Nathalie A C H NA Margaritis Thanasis T van de Pasch Loes A L LA van Heesch Sebastiaan A A C SA Brok Mariel O MO Groot Koerkamp Marian J A MJ Ko Cheuk W CW van Leenen Dik D Sameith Katrin K van Hooff Sander R SR Lijnzaad Philip P Kemmeren Patrick P Hentrich Thomas T Kobor Michael S MS Buratowski Stephen S Holstege Frank C P FC
Molecular cell 20110501 4
Packaging of DNA into chromatin has a profound impact on gene expression. To understand how changes in chromatin influence transcription, we analyzed 165 mutants of chromatin machinery components in Saccharomyces cerevisiae. mRNA expression patterns change in 80% of mutants, always with specific effects, even for loss of widespread histone marks. The data are assembled into a network of chromatin interaction pathways. The network is function based, has a branched, interconnected topology, and la ...[more]