Ontology highlight
ABSTRACT:
SUBMITTER: Marangoni RG
PROVIDER: S-EPMC4437446 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Marangoni Roberta Goncalves RG Korman Benjamin D BD Allanore Yannick Y Dieude Philippe P Armstrong Loren L LL Rzhetskaya Margarita M Hinchcliff Monique M Carns Mary M Podlusky Sofia S Shah Sanjiv J SJ Ruiz Barbara B Hachulla Eric E Tiev Kiet K Cracowski Jean-Luc JL Varga John J Hayes M Geoffrey MG
Arthritis research & therapy 20150519
<h4>Introduction</h4>The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis (SSc). We investigated PPAR-γ gene (PPARG) single nucleotide polymorphisms (SNPs) associated with SSc.<h4>Methods</h4>Tag SNPs spanning PPARG were genotyped in a European ancestry US discovery cohort comprising 152 SSc patients and 450 controls, with replication of our ...[more]