Ontology highlight
ABSTRACT:
SUBMITTER: Siller R
PROVIDER: S-EPMC4437467 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Siller Richard R Greenhough Sebastian S Naumovska Elena E Sullivan Gareth J GJ
Stem cell reports 20150430 5
The differentiation of pluripotent stem cells to hepatocytes is well established, yet current methods suffer from several drawbacks. These include a lack of definition and reproducibility, which in part stems from continued reliance on recombinant growth factors. This has remained a stumbling block for the translation of the technology into industry and the clinic for reasons associated with cost and quality. We have devised a growth-factor-free protocol that relies on small molecules to differe ...[more]