Ontology highlight
ABSTRACT:
SUBMITTER: Holtzinger A
PROVIDER: S-EPMC4689216 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Holtzinger Audrey A Streeter Philip R PR Sarangi Farida F Hillborn Scott S Niapour Maryam M Ogawa Shinichiro S Keller Gordon G
Development (Cambridge, England) 20151022 24
The efficient generation of hepatocytes from human pluripotent stem cells (hPSCs) requires the induction of a proper endoderm population, broadly characterized by the expression of the cell surface marker CXCR4. Strategies to identify and isolate endoderm subpopulations predisposed to the liver fate do not exist. In this study, we generated mouse monoclonal antibodies against human embryonic stem cell-derived definitive endoderm with the goal of identifying cell surface markers that can be used ...[more]