Ontology highlight
ABSTRACT:
SUBMITTER: Xia W
PROVIDER: S-EPMC4437472 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Xia Wenlong W Liu YanLi Y Jiao Jianwei J
Stem cell reports 20150423 5
Metabotropic glutamate receptor 7 (GRM7) has recently been identified to be associated with brain developmental defects, such as attention deficit hyperactivity disorder (ADHD) and autism. However, the function of GRM7 during brain development remains largely unknown. Here, we used gain- and loss-of-function strategies to investigate the role of GRM7 in early cortical development. We demonstrate that Grm7 knockdown increases neural progenitor cell (NPC) proliferation, decreases terminal mitosis ...[more]