Ontology highlight
ABSTRACT:
SUBMITTER: Flanagan DJ
PROVIDER: S-EPMC4437483 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Stem cell reports 20150416 5
The mammalian adult small intestinal epithelium is a rapidly self-renewing tissue that is maintained by a pool of cycling stem cells intermingled with Paneth cells at the base of crypts. These crypt base stem cells exclusively express Lgr5 and require Wnt3 or, in its absence, Wnt2b. However, the Frizzled (Fzd) receptor that transmits these Wnt signals is unknown. We determined the expression profile of Fzd receptors in Lgr5(+) stem cells, their immediate daughter cells, and Paneth cells. Here we ...[more]