Ontology highlight
ABSTRACT:
SUBMITTER: Al-Tassan NA
PROVIDER: S-EPMC4438486 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Al-Tassan Nada A NA Whiffin Nicola N Hosking Fay J FJ Palles Claire C Farrington Susan M SM Dobbins Sara E SE Harris Rebecca R Gorman Maggie M Tenesa Albert A Meyer Brian F BF Wakil Salma M SM Kinnersley Ben B Campbell Harry H Martin Lynn L Smith Christopher G CG Idziaszczyk Shelley S Barclay Ella E Maughan Timothy S TS Kaplan Richard R Kerr Rachel R Kerr David D Buchanan Daniel D DD Win Aung Ko AK Hopper John J Jenkins Mark M Lindor Noralane M NM Newcomb Polly A PA Gallinger Steve S Conti David D Schumacher Fred F Casey Graham G Dunlop Malcolm G MG Tomlinson Ian P IP Cheadle Jeremy P JP Houlston Richard S RS
Scientific reports 20150520
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes utilising the 1000 Genomes Project. The combined analysis identified new, significant ...[more]