Ontology highlight
ABSTRACT:
SUBMITTER: Mackay EM
PROVIDER: S-EPMC4438726 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Mackay Emily M EM Koppel Jennifer J Das Pooja P Woo Joanna J Schriemer David C DC Bathe Oliver F OF
Cancer informatics 20150517
In recent years, hundreds of candidate protein biomarkers have been identified using discovery-based proteomics. Despite the large number of candidate biomarkers, few proteins advance to clinical validation. We propose a hypothesis-driven approach to identify candidate biomarkers, previously characterized in the literature, with the highest probability of clinical applicability. A ranking method, called the "hypothesis-directed biomarker ranking" (HDBR) system, was developed to score candidate b ...[more]