Ontology highlight
ABSTRACT:
SUBMITTER: Rivera LB
PROVIDER: S-EPMC4438771 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Rivera Lee B LB Meyronet David D Hervieu Valérie V Frederick Mitchell J MJ Bergsland Emily E Bergers Gabriele G
Cell reports 20150416 4
Antiangiogenic therapy is commonly used in the clinic, but its beneficial effects are short-lived, leading to tumor relapse within months. Here, we found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in mouse models of pancreatic neuroendocrine and mammary tumors. In response, tumors reinitiated angiogenesis and immune suppression by activating PI3K signaling in all CD11b+ cells, r ...[more]