Ontology highlight
ABSTRACT:
SUBMITTER: Schuster C
PROVIDER: S-EPMC4439257 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Schuster Cornelia C Gerold Kay D KD Schober Kilian K Probst Lilli L Boerner Kevin K Kim Mi-Jeong MJ Ruckdeschel Anna A Serwold Thomas T Kissler Stephan S
Immunity 20150512 5
CLEC16A variation has been associated with multiple immune-mediated diseases, including type 1 diabetes, multiple sclerosis, systemic lupus erythematosus, celiac disease, Crohn's disease, Addison's disease, primary biliary cirrhosis, rheumatoid arthritis, juvenile idiopathic arthritis, and alopecia areata. Despite strong genetic evidence implicating CLEC16A in autoimmunity, this gene's broad association with disease remains unexplained. We generated Clec16a knock-down (KD) mice in the nonobese d ...[more]