Ontology highlight
ABSTRACT:
SUBMITTER: Martinic MM
PROVIDER: S-EPMC149924 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Martinic Marianne M MM Rülicke Thomas T Althage Alana A Odermatt Bernhard B Höchli Matthias M Lamarre Alain A Dumrese Tilman T Speiser Daniel E DE Kyburz Diego D Hengartner Hans H Zinkernagel Rolf M RM
Proceedings of the National Academy of Sciences of the United States of America 20030206 4
Nonthymic epithelial cells were compared with thymic epithelial cells for their role in T cell repertoire selection. Tetraparental aggregation chimeras were generated from T and B cell-deficient mice (H-2(d) SCID or H-2(b) Rag-/-) and thymus-deficient nude mice (H-2(b) or H-2(d)). These tetraparental mice showed primary protective CD8(+) T cell responses, after lymphocytic choriomeningitis virus infection, that were peptide-specifically restricted to either thymic or nonthymic epithelial MHC at ...[more]