Interleukin polymorphisms in aggressive periodontitis: A literature review.
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ABSTRACT:
SUBMITTER: Maney P
PROVIDER: S-EPMC4439620 | biostudies-literature | 2015 Mar-Apr
REPOSITORIES: biostudies-literature
Publications
Interleukin polymorphisms in aggressive periodontitis: A literature review.
Maney Pooja P Owens Jessica Leigh JL
Journal of Indian Society of Periodontology 20150301 2
Aggressive periodontitis (AgP), occurs in a younger age group (≤35 years) and is associated with the rapid destruction of periodontal attachment and supporting bone. Genetic polymorphisms are allelic variants that occur in at least 1% of the population that could potentially alter the function of the proteins that they encode. Interleukins are a group of cytokines that have complex immunological functions including proliferation, migration, growth and differentiation of cells and play a key role ...[more]
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Project description:ContextInterleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection.AimsThis study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene.Settings and designThis is a cross-sectional, biochemical, genetic study.Materials and methodsNinety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism.ResultsA significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33.ConclusionsIL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.
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2017-09-26 | GSE103413 | GEO
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