Dataset Information

Interleukin-1? rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.

ABSTRACT: Multiple studies had focused on the association between interleukin-1 (IL-1) rs1143634 polymorphism and aggressive periodontitis (AgP) susceptibility, but the results remained inconclusive. Therefore, this meta-analysis was conducted to explore its role in the development of AgP. PubMed and Embase databases were searched up to April 15, 2014. After study selection and data extraction form eligible studies, meta-analysis was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the association. All the analysis was performed using Comprehensive Meta-Analysis software. Finally a total of 25 case-control studies were included. The pooled results showed non-association between AgP susceptibility and IL-1 rs1143634 polymorphism [for T vs. C: OR = 0.99, 95% CI = 0.79-1.23; for TT vs. CC: OR = 1.14, 95% CI = 0.78-1.66; for CT vs. CC: OR = 0.97, 95% CI = 0.70-1.36; for (CT + TT) vs. CC: OR = 1.02, 95% CI = 0.76-1.37; for TT vs. (CT + CC): OR = 1.22, 95% CI = 0.85-1.75]. Subgroup analyses remain did not find any association. No publication bias was detected. Hence, our meta-analysis showed that IL-1? rs1143634 polymorphism is not linked to AgP susceptibility, regardless of ethnicity.

SUBMITTER: Chen YJ

PROVIDER: S-EPMC4402814 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Interleukin-1β rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.

Chen Yong-Ji YJ Han Ying Y Mao Min M Tan Ya-Qin YQ Leng Wei-Dong WD Zeng Xian-Tao XT

International journal of clinical and experimental medicine 20150215 2

Multiple studies had focused on the association between interleukin-1 (IL-1) rs1143634 polymorphism and aggressive periodontitis (AgP) susceptibility, but the results remained inconclusive. Therefore, this meta-analysis was conducted to explore its role in the development of AgP. PubMed and Embase databases were searched up to April 15, 2014. After study selection and data extraction form eligible studies, meta-analysis was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were use ...[more]

PMID: 25932167

Similar Datasets

Project description:BackgroundMatrix metalloproteinase-1 (MMP-1) plays an important role during the destruction of periodontal tissue. Although multiple studies had focused on the association between MMP-1 g.-1607dupG and periodontitis susceptibility, the results remained inconclusive. The purpose of this meta-analysis was to explore its role in the development of periodontitis.MethodsRetrieved studies from Pubmed, Web of Science, Medline and Google Scholar Search regarding MMP-1 g.-1607dupG and periodontitis susceptibility were included into the final analysis with definite selection and exclusion criteria. Overall and stratified analyses based on disease type, severity, ethnicity and smoking status were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between MMP-1 g.-1607dupG and periodontitis susceptibility, while Q test and Egger's test were adopted respectively to assess heterogeneity among studies and publication bias.ResultsA total of 1580 periodontitis cases and 1386 controls in 11 case-control studies were included in the meta-analysis. The pooled results showed significant association between periodontitis susceptibility and MMP-1 g.-1607dupG polymorphism in homozygote (2G/2G versus 1G/1G, OR?=?1.50, 95% CI?=?1.02-2.20) and dominant model analysis (2G/2G+2G/1G versus 1G/1G, OR?=?1.28, 95% CI?=?1.04-1.57). For subgroups by type of periodontitis, increased risk of chronic periodontitis was observed on heterozygote (2G/1G versus 1G/1G, OR?=?2.01, 95% CI?=?1.58-2.56) and dominant model (OR?=?1.27, 95% CI?=?1.03-1.57). Furthermore, similar association was also detected in severe chronic periodontitis (2G/2G versus 1G/1G, OR?=?2.15, 95% CI?=?1.35-3.43; 2G/2G+2G/1G versus 1G/1G, OR?=?1.64, 95% CI?=?1.12-2.39; 2G/2G versus 2G/1G+1G/1G, OR?=?1.86, 95% CI?=?1.31-2.64).ConclusionsOur meta-analysis demonstrated that MMP-1 g.-1607dupG polymorphism was associated with chronic periodontitis, especially the severity of the disease condition.

Dataset Information

Interleukin-1? rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.

Publications

Interleukin-1β rs1143634 polymorphism and aggressive periodontitis susceptibility: a meta-analysis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure