Ontology highlight
ABSTRACT:
SUBMITTER: Piao MX
PROVIDER: S-EPMC4440094 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Piao Ming-Xue MX Bai Ji-Wei JW Zhang Peng-Fei PF Zhang Ya-Zhuo YZ
International journal of clinical and experimental pathology 20150301 3
Proprotein convertase subtilisin/kexin type 9 (PCSK9), belongs to a family of proprotein convertases (PCs), encodes a neural apoptosis-regulated convertase 1. However, the precise role of PCSK9 during glioma cells apoptosis has not been reported. Therefore, we examined the effects of knockdown and overexpression of PCSK9 on apoptosis of human neuroglioma U251 cells, and investigated the underlying mechanisms of apoptosis. We found that PCSK9 regulated cells proliferation as determined by CCK-8 a ...[more]