Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC4440243 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Ma Xiaodong X Conklin Daniel J DJ Li Fenge F Dai Zhongping Z Hua Xiang X Li Yan Y Xu-Monette Zijun Y ZY Young Ken H KH Xiong Wei W Wysoczynski Marcin M Sithu Srinivas D SD Srivastava Sanjay S Bhatnagar Aruni A Li Yong Y
Nature communications 20150520
MicroRNAs (miRNAs) regulate apoptosis, yet their role in regulated necrosis remains unknown. miR-21 is overexpressed in nearly all human cancer types and its role as an oncogene is suggested to largely depend on its anti-apoptotic action. Here we show that miR-21 is overexpressed in a murine model of acute pancreatitis, a pathologic condition involving RIP3-dependent regulated necrosis (necroptosis). Therefore, we investigate the role of miR-21 in acute pancreatitis injury and necroptosis. miR-2 ...[more]