JBP485 promotes tear and mucin secretion in ocular surface epithelia.
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ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC4440520 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
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JBP485 promotes tear and mucin secretion in ocular surface epithelia.
Nakamura Takahiro T Hata Yuiko Y Nagata Maho M Yokoi Norihiko N Yamaguchi Shumpei S Kaku Taiichi T Kinoshita Shigeru S
Scientific reports 20150521
Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis of the wet ocular surface. Since there are a limited number of clinical options for the treatment of DES, additional novel treatments are needed to improve the clinical results. In this study, we found that placental extract-derived dipeptide (JBP485) clearly promoted the expression and secr ...[more]
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