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Lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA) MRI.

ABSTRACT: PURPOSE:The Dixon techniques provide uniform water-fat separation but require multiple image sets, which extend the overall acquisition time. Here, an alternative rapid single acquisition method, lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA), was introduced. METHODS:The LEENA method utilized a fast imaging with steady-state free precession sequence to obtain a single k-space dataset in which successive k-space lines are acquired to allow the fat magnetization to precess 180°. The LEENA data were then unghosted using either image-domain (LEENA-S) or k-space domain (LEENA-G) parallel imaging techniques to reconstruct water-only and fat-only images. An off-resonance correction technique was incorporated to improve the uniformity of the water-fat separation. RESULTS:Uniform water-fat separation was achieved for both the LEENA-S and LEENA-G methods for phantom and human body and leg imaging applications at 1.5T and 3T. The resultant water and fat images were qualitatively similar to conventional 2-point Dixon and fat-suppressed images. CONCLUSION:The LEENA-S and LEENA-G methods provide uniform water and fat images from a single MRI acquisition. These straightforward methods can be adapted to 1.5T and 3T clinical MRI scanners and provide comparable fat/water separation with conventional 2-point Dixon and fat-suppression techniques.

SUBMITTER: Lu L

PROVIDER: S-EPMC4441038 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA) MRI.

Lu Lan L Donnola Shannon B SB Koontz Michaela M Griswold Mark A MA Duerk Jeffrey L JL Flask Chris A CA

Magnetic resonance in medicine 20140317 2

<h4>Purpose</h4>The Dixon techniques provide uniform water-fat separation but require multiple image sets, which extend the overall acquisition time. Here, an alternative rapid single acquisition method, lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA), was introduced.<h4>Methods</h4>The LEENA method utilized a fast imaging with steady-state free precession sequence to obtain a single k-space dataset in which successive k-space lines are acquired to allow the fat magnetizati ...[more]

PMID: 24639034

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Project description:Background Myocardial oxygenation imaging could help determine the presence of microvascular dysfunction associated with increased cardiovascular risk. However, it is challenging to depict the potentially small oxygenation alterations with current noninvasive cardiac MRI blood oxygen level-dependent (BOLD) techniques. Purpose To demonstrate the cardiac application of a gradient-echo spin-echo (GESE) echo-planar imaging sequence for dynamic and quantitative heartbeat-to-heartbeat BOLD MRI and evaluate the sequence in populations both healthy and with hypertension in combination with a breath hold-induced CO2 intervention. Materials and Methods GESE echo-planar imaging sequence was performed in 18 healthy participants and in eight prospectively recruited participants with hypertension on a 3.0-T MRI system. T2 and T2* maps were calculated per heartbeat with a four-parameter fitting technique. Septal regions of interests were used to determine T2 and T2* values per heartbeat and examined over the course of a breath hold to determine BOLD changes. T2 and T2* changes of healthy participants and participants with hypertension were compared by using a nonparametric Mann-Whitney test. Results GESE echo-planar imaging approach gave spatially stable T2 and T2* maps per heartbeat for healthy participants and participants with hypertension, with mean T2 values of 43 msec ± 5 (standard deviation) and 46 msec ± 9, respectively, and mean T2* values of 28 msec ± 5 and 22 msec ± 5, respectively. The healthy participants exhibited increasing T2 and T2* values over the course of a breath hold with a mean positive slope of 0.2 msec per heartbeat ± 0.1 for T2 and 0.2 msec per heartbeat ± 0.1 for T2*, whereas for participants with hypertension these dynamic T2 and T2* values had a mean negative slope of -0.2 msec per heartbeat ± 0.2 for T2 and -0.1 msec per heartbeat ± 0.2 for T2*. The difference in these mean slopes between healthy participants and participants with hypertension was significant for both T2 (P < .001) and T2* (P < .001). Conclusion Gradient-echo spin-echo echo-planar imaging sequence provided quantitative T2 and T2* maps per heartbeat and enabled dynamic heartbeat-to-heartbeat blood oxygen level-dependent (BOLD)-response imaging by analyzing changes in T2 and T2* over the time of a breath-hold intervention. This approach could identify differences in the BOLD response between healthy participants and participants with hypertension. © RSNA, 2020 Online supplemental material is available for this article. See also the editorial by Friedrich in this issue.

Dataset Information

Lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA) MRI.

Publications

Lipid elimination with an echo-shifting N/2-ghost acquisition (LEENA) MRI.

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