Ontology highlight
ABSTRACT:
SUBMITTER: Szolek A
PROVIDER: S-EPMC4441069 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Szolek András A Schubert Benjamin B Mohr Christopher C Sturm Marc M Feldhahn Magdalena M Kohlbacher Oliver O
Bioinformatics (Oxford, England) 20140820 23
<h4>Motivation</h4>The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive immunity and is thus relevant in many biomedical applications. While next-generation sequencing data are often available for a patient, deducing the HLA genotype is difficult because of substantial sequence similarity within the cluster and exceptionally high variability of the loci. Established approaches, therefore, rely on specific HLA enrichment and sequencing techniques, coming at an additiona ...[more]