Ontology highlight
ABSTRACT:
SUBMITTER: Lorenzana AO
PROVIDER: S-EPMC4441580 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Lorenzana Ariana O AO Lee Jae K JK Mui Matthew M Chang Amy A Zheng Binhai B
Neuron 20150430 4
The complex morphology of axons presents a challenge in understanding axonal responses to injury and disease. By in vivo two-photon imaging of spinal dorsal column sensory axons, we systematically examined the effect of injury location relative to the main bifurcation point on axon degeneration and regeneration following highly localized laser injuries. Retrograde but not anterograde degeneration was strongly blocked at the bifurcation point at both the acute and subacute phases. Eliminating eit ...[more]