A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance.
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ABSTRACT:
SUBMITTER: Gabor KA
PROVIDER: S-EPMC4442029 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance.
Gabor K A KA Charette J R JR Pietraszewski M J MJ Wingfield D J DJ Shim J S JS Millard P J PJ Kim C H CH
Developmental and comparative immunology 20150126 2
Melanoma Differentiation-Associated protein 5 (MDA5) is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family, which is a cytosolic pattern recognition receptor that detects viral nucleic acids. Here we show an Mda5-dependent response to rhabdovirus infection in vivo using a dominant-negative mda5 transgenic zebrafish. Dominant-negative mda5 zebrafish embryos displayed an impaired antiviral immune response compared to wild-type counterparts that can be rescued by reco ...[more]
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