Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression.
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ABSTRACT:
SUBMITTER: Brulois K
PROVIDER: S-EPMC4442431 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression.
Brulois Kevin K Wong Lai-Yee LY Lee Hye-Ra HR Sivadas Priyanka P Ensser Armin A Feng Pinghui P Gao Shou-Jiang SJ Toth Zsolt Z Jung Jae U JU
Journal of virology 20150325 11
Transcription of herpesvirus late genes depends on several virus-encoded proteins whose function is not completely understood. Here, we identify a viral trimeric complex of Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 31 (ORF31), ORF24, and ORF34 that is required for late gene expression but not viral DNA replication. We found that (i) ORF34 bridges the interaction between ORF31 and ORF24, (ii) the amino-terminal cysteine-rich and carboxyl-terminal basic domains of ORF31 med ...[more]
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