Ontology highlight
ABSTRACT:
SUBMITTER: Himmelein S
PROVIDER: S-EPMC4442501 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Journal of virology 20150311 10
Herpes simplex virus 1 (HSV-1) can establish lifelong latency in human trigeminal ganglia. Latently infected ganglia contain CD8(+) T cells, which secrete granzyme B and are thus capable of inducing neuronal apoptosis. Using immunohistochemistry and single-cell reverse transcription-quantitative PCR (RT-qPCR), higher frequency and transcript levels of caspase-3 were found in HSV-1-negative compared to HSV-1-positive ganglia and neurons, respectively. No terminal deoxynucleotidyltransferase-media ...[more]