Ontology highlight
ABSTRACT:
SUBMITTER: Bijata M
PROVIDER: S-EPMC4443029 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bijata Monika M Wlodarczyk Jakub J Figiel Izabela I
Frontiers in cellular neuroscience 20150526
Dendritic outgrowth and arborization are important for establishing neural circuit formation. To date, little information exists about the involvement of the extracellular matrix (ECM) and its cellular receptors in these processes. In our studies, we focus on the role of dystroglycan (DG), a cell adhesion molecule that links ECM components to the actin cytoskeleton, in dendritic development and branching. Using a lentiviral vector to deliver short-hairpin RNA (shRNA) that specifically silences D ...[more]