Ontology highlight
ABSTRACT:
SUBMITTER: Leiserson MD
PROVIDER: S-EPMC4444046 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20141215 2
Cancers exhibit extensive mutational heterogeneity, and the resulting long-tail phenomenon complicates the discovery of genes and pathways that are significantly mutated in cancer. We perform a pan-cancer analysis of mutated networks in 3,281 samples from 12 cancer types from The Cancer Genome Atlas (TCGA) using HotNet2, a new algorithm to find mutated subnetworks that overcomes the limitations of existing single-gene, pathway and network approaches. We identify 16 significantly mutated subnetwo ...[more]