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Enantioselective cis-?-lactam synthesis by intramolecular C-H functionalization from enoldiazoacetamides and derivative donor-acceptor cyclopropenes.

ABSTRACT: ?-Lactam derivatives are produced through intermediate donor-acceptor cyclopropene intermediates in high yield, exclusive cis-diastereoselectivity, and high enantiocontrol in a chiral dirhodium carboxylate catalyzed intramolecular C-H functionalization reaction of enoldiazoacetamides.

SUBMITTER: Xu X

PROVIDER: S-EPMC4444070 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Enantioselective <i>cis</i>-β-lactam synthesis by intramolecular C-H functionalization from enoldiazoacetamides and derivative donor-acceptor cyclopropenes.

Xu Xinfang X Deng Yongming Y Yim David N DN Zavalij Peter Y PY Doyle Michael P MP

Chemical science 20150401 4

β-Lactam derivatives are produced through intermediate donor-acceptor cyclopropene intermediates in high yield, exclusive cis-diastereoselectivity, and high enantiocontrol in a chiral dirhodium carboxylate catalyzed intramolecular C-H functionalization reaction of enoldiazoacetamides. ...[more]

PMID: 26029355

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